The Catalyst 3750-E Series Switches are compatible with the Cisco Catalyst 3750 Series Switches, enabling customers to stack them together and thereby protect existing investment in the Cisco Catalyst 3750 Series Switches. The Cisco TwinGig Small Form-Factor Pluggable (SFP) converter module further protects customers' investment in the Cisco Catalyst 3750-E Series Switches by enabling migration from to 10 Gigabit Ethernet uplinks, as business needs require, without having to upgrade the switches.

The Cisco Catalyst 3750-E Series is available with either the IP Base feature set or the IP Services feature set. The IP Base feature set includes advanced quality of service (QoS), a suite of security features, rate-limiting, ACLs, and basic static and Routing Information Protocol (RIP) routing capability. The IP Services feature set provides a richer set of enterprise-class features, including advanced hardware-based IP unicast and multicast routing-Enhanced Interior Gateway Routing Protocol (EIGRP), Open Shortest Path First (OSPF), Border Gateway Protocol (BGP), Protocol Independent Multicast (PIM), and so on.